This research investigates the implications of U.S. military support to Israel on its relationship with Iran, particularly in escalating proxy conflicts in the Middle East. The study contends that the U.S. administration’s consistent military assistance aimed at bolstering Israel's defence capabilities against Iranian-backed proxy groups significantly influences the dynamics of U.S.-Iran regional interactions. Utilizing a mixed-methods approach, the study incorporates qualitative data from interviews uncovering themes such as asymmetric dynamics, domestic political influences, threat perceptions, and regional instability. Findings reveal that U.S. support for Israel fosters an environment of mistrust and escalated tensions, prompting Iran to reinforce its involvement with proxy groups. The research ultimately suggests policy adjustments for the U.S. administration, advocating for a reassessment of military support to Israel, emphasizing multilateral negotiations addressing regional complexities, and maximizing efforts to promote Palestinian self-determination as pathways to enhance strategic interaction with Iran and contribute to greater stability in the region